What Are Non-Steroidal Anti-Inflammatory Drugs?

All drugs are classified in terms of either their active ingredients or how they are used to treat a particular condition. Moreover, a specific drug may fall into one or more of these specific drug classes. Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of drugs that all have similar analgesic, antipyretic, and anti-inflammatory properties. Though the individual drugs that fall within this class of medications differ in chemical structure, they are grouped together in this class due to their action of blocking the enzyme cyclo-oxygenase (COX). By blocking this enzyme, NSAIDs act to inhibit the production of thromboxanes and prostaglandins, which are both products of the inflammatory response.

There are two types of COX enzymes that exist, both of which play a key role in inflammation, fever, and pain. COX-1 enzymes are located in nearly every type of tissue within the body, including the stomach and platelets. The COX-1 enzymes, in particular, are responsible for regulating the production of prostaglandins. COX-2 enzymes are generally found within inflammatory cells, once they become activated. Though the precise mechanism of action behind the analgesic, antipyretic, and anti-inflammatory properties of NSAIDs is not fully understood, it is believed that these benefits can be accounted for in part by blocking COX enzymes and, thereby, reducing the amount of prostaglandins within the body.

NSAIDs-Aspirine-macro-shotIn addition to their role in inflammation and pain, COX enzymes are involved in other key functions within the body. In particular, COX enzymes help protect the lining of the stomach from the acid of its own digestive fluids. So while NSAIDs can provide patients with significant relief from symptoms of inflammation, fever, and pain, taking these types of medication can also leave the stomach vulnerable to damage, including ulcers and bleeding.

A newer type of NSAID available is known as the COX-2 inhibitor. COX-2 inhibitors provide the anti-inflammatory effects of blocking the COX-2 enzyme, but do not affect the COX-1 enzyme, reducing the risk of stomach or intestinal damage. COX-2 inhibitors are ideal for patients who are considered to be at an elevated risk for developing stomach or intestinal problems; however, COX-2 inhibitors can increase the risk for